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doi: 10.1007/s10815-012-9714-1 194 YoussefMAAbdelmotyHIElashmwiHAAbduljawadEMElghamaryNMagdyAet al

John Dick's group had originally identified the AML LSCs in primary patients using serial xenotransplantation experiments in NOD/SCID immunodeficient mice and observed that LSCs reside in lineage-CD34 + CD38 cells fraction ( + cells enriches the LSCs frequency ( AML LSCs and blasts reside in bone marrow (BM) niches, where the nutrients are limited