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In a T cell-mediated chronic psoriasiform inflammation model, investigators observed the coexistence of pro-inflammatory macrophages expressing iNOS and alternatively activated macrophages expressing Arg1 in lesional tissues, suggesting that the partitioning of arginine metabolic pathways participates in regulating macrophage phenotypes and the intensity of inflammatory responses

[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Valko M., Jomova K., Rhodes C.J., Kuca K., Musilek K

Wang J, Zhang Y, et al

Mitochondria-mediated apoptosis constitutes a key pathway for dopaminergic neuron death in PD, yet neurons lack functional Bcl-2 expressiontheir anti-apoptotic function is primarily mediated by Bcl-xL [30]