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Anal Chem 2005, 77 (20):6588-6593

Doubling the maximum daily dose of over-the-counter pain killers such as aspirin or ibuprofen may slightly increase a persons risk for bleeding, in the stomach and gastrointestinal tract, he wrote, but it is not even close to the seriousness presented by doubling the dose of acetaminophen, which can lead to liver failure

Early-stage Lung Cancer International eXpert Retreat - #ELIXR24

The stability of atherosclerotic plaques is closely related to the size of the lipid core, the thickness of the fiber cap and the number of inflammatory cells within the plaque (77)

However, some of the studies used injected SAMe, which may not have the same effects as SAMe taken as a dietary supplement