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However, in advanced HF, persistent AMPK activation has been associated with transcriptional suppression of CPT1, accelerating the decline in FAO capacity and reinforcing metabolic rigidity (Wang et al., 2009)

Furthermore, the differential metabolite of walengzi, N6-isopentenyladenosine, induces S/G2 arrest and apoptosis in thyroid cancer TPC-1 cells (Sun et al., 2017)

Thus, the regulatory effect of natural small molecule compounds on ferroptosis, especially on the treatment of kidney diseases, has attracted wide attention