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Sublingual B12 was administered in laboratory conditions, where there was no dose omission, making it difficult to extrapolate real-world effects, where patient compliance may not be as good

18 Support for the poorer bioavailability of cyano-B12 comes from a study comparing sublingual cyano- with methyl-B12 (both 1000 g per day), which found that both forms led to a normalisation of B12 status, but B12 levels increased significantly more in the methyl-B12 form compared with the cyano-B12 form, although the formulations also had other differences the former was a tablet, the latter a spray

Its importance as a flexible tool in medical and wellness applications is shown by its complex involvement in both reproductive and general health

If women are B12 deficient whilst pregnant or breastfeeding, it can lead to serious development problems in the childs brain (7)

It also gives laboratories a clearer way to separate this format from single-compound products that do not offer the same paired-pathway perspective