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Based on the data available, the association between eight Indian spices (black cumin, black pepper, curry leaf tree, fenugreek, fennel, coriander, cumin, and cardamom) and several age-related neurological diseases such as Parkinsons disease, Alzheimers disease, dementia, epilepsy, multiple sclerosis, cerebrovascular disorders, traumatic brain injury, Huntingtons disease, and brain tumor was summarized

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This nerve damage may result from diabetes, vitamin deficiencies, autoimmune disease, chemotherapy, alcohol or drug misuse, and other causes

Under homeostatic conditions, NRF2 is sequestered in the cytoplasm through its interaction with the repressor protein KEAP1

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