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The absence of alteration of the intestinal mucosa, which indicates the absence of toxicity and preservation of physiology and gastrointestinal integrity, was also verified by visual inspection

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Although the modes of action for both GH43_8 and AA5 are currently unknown their enrichment in the AGAu group may provide a function-targeted biomarker for Candida infections 135,136

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Consistent with this possibility, we found that continuing dilution of M22 to 1M, while clearly demonstrating intact synapses and pre-synaptic vesicles, also led to areas of tissue disruption suggestive of excessive osmotic swelling