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The study found that while glutathione was elevated, other vital protective antioxidant enzymessuch as mitochondrial superoxide dismutase (SOD2)were severely depleted

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Our work establishes a new enzyme class for proximity labeling with promising properties and paves the way for future improvements

Combination data with diet suggest complementary mechanisms, and reviews highlight continued medicinal-chemistry work to tune potency, selectivity, and exposure for future translational studies