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Stromal cell-derived factor-1 (SDF-1) is a small molecule cytokine capable of recruiting these repair cells

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Conversely, excessive ROS accumulation leads to DNA damage, induction of p53 and Fas ligand (FasL), and ultimately T cell apoptosis ( Figure 1 ), which can be advantageous in terms of controlling autoimmunity ( Figure 1 Given this finite balance, it is not surprising that ROS are generated by multiple pathways following TCR activation and, in parallel, eliminated by multiple antioxidant systems

Second, developing highly specific intervention tools is key to overcoming off-target effects

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