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These types of chromosome aberrations are the consequence of asymmetrical chromosome translocations where the genetic material is recombined in what has been termed an illegitimate manner (e.g., a chromosome containing an extra centromere)

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Glick, HA

Examples of mechanisms that produce such changes are DNA methylation and histone modification, each of which alters how genes are expressed without altering the underlying DNA sequence

When GPX4 activity diminishes, lipid peroxidation proceeds unimpeded, consequently triggering ferroptosis (22)

Moreover, in the murine inflammatory bowel disease model, a reduction in neutrophil migration was demonstrated through the blockade of the CD128 chemokine receptor (132)