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New study reveals specialised subpopulations of head direction cells in the mouse thalamus 10 June 2026 Researchers from the Viney Group in the Department of Pharmacology, along with collaborators from The Center for Systems Neuroscience, Boston University, US, have identified distinct subpopulations of head direction (HD) cells in the mouse thalamus, revealing that the brain's internal compass is composed of specialised neurons that differ in their sensorimotor responses, molecular identity, and connectivity

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For sorting, portal fibroblasts were stained with anti-human CD90 (THY1) conjugated to APC, anti-human CD140a (PDGFR) conjugated to PE, anti-CD11b/CD31/CD45 conjugated to PECy7 and anti-EpCAM conjugated to Alexa 488 for 30 min on ice and washed twice