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4.1.4 Gutbone axis and periodontitis Periodontitis is a chronic infectious disease caused by periodontal pathogenic bacteria, which stimulates the differentiation of osteoclasts while inducing periodontal inflammation, resulting in alveolar bone resorption (106)

rebaudiana has long been incorporated into traditional prescriptions for modulating metabolic functions and assisting in glycemic and weight control (Tipduangta et al., 2019

Using high-throughput TMT-based quantification with high-resolution mass spectroscopy, 9802 proteins were simultaneously identified and quantified, the highest number so far reported in the literature