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2 Table 2 Clinical Manifestations of Vitamin B12 Deficiency Maternal vitamin B 12 deficiency during pregnancy or while breastfeeding may lead to neural tube defects, developmental delay, failure to thrive, hypotonia, ataxia, and anemia

Loading For deficiency without neurological features, the standard loading regimen is hydroxocobalamin 1mg intramuscularly three times a week for two weeks, six injections in total

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohns disease

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