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In cohort 2, 8 eyes showed substantial improvement in MMS and heatmaps (Figure 6, IP, and Supplemental Figures 20, 21, 22, 25, 29, and 32) and 7 eyes showed little change or worsening (Supplemental Figures 23, 24, 2628, 31, and 33)

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Embodiment 61 of this disclosure are compounds of Formula I, I-a, or I-b, or Embodiments 1-60, or a class thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein R 8a and R 8b are independently selected from hydrogen or (C 1-3 )alkyl