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Repeated dosing studies in rats, dogs, and mice for up to 6 weeks across doses from 0.006 mg/kg to 20 mg/kg via multiple routes showed excellent tolerance

One reason for this may be that the body needs vitamin B12 to process homocysteine

The accumulation factor (equation [7]) assumes that the drug follows a one-compartment model ( Figure 32 B), and the peak concentration prediction assumes that the absorption rate is much faster than the elimination rate

By the onset of proximal tubule dysfunction apoptosis begins in low number of cells (5%)

typically improves with continued use 2 Skin irritation, stinging, or a warm sensation, especially in those with sensitive skin Increased sun sensitivity tretinoin makes the skin more vulnerable to UV damage