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Redner A, Melamed MR, Andreeff M

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CDK4/6 are inactivated by p16INK4A, promoting the accumulation of phosphorylated Rb and the inactivation of E2F transcription, which induces senescence

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However, it is possible that in analogy to their role in neurological disorders, GAD65Ab are taken up by pancreatic beta cells and (a) uncouple the balanced regulation of insulin and glucagon secretion and (b) induce beta cell apoptosis through prolonged exposure to elevated extracellular glutamate levels