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demonstrated that, under physiological conditions, macrophages could, uptake native Hb without the binding protein Hp through CD163 ( Another early study also suggests the existence of a novel clearance pathway

doi: 10.3389/fendo.2025.1722623 Received 11 October 2025 Revised 11 November 2025 Accepted 12 November 2025 Published 26 November 2025 Volume 16 - 2025 Edited by Roma Patel, Albert Einstein College of Medicine, United States Reviewed by Xue Xiaoyong, Beijing University of Chinese Medicine, China Updates Copyright 2025 Ling, Schultz, Knight, Shearn and Baumel-Alterzon

(137) found that although Mv can inhibit the NF-B pathway by blocking the nuclear translocation of p65, this process does not rely on the degradation of IB or the activation of IKK

v-ATPase complex vulnerability underlying neurodegenerative disease gained initial attention from studies of presenilin 1 (PSEN1), mutations of which cause the most common inherited form of AD 110