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They have been known to trigger attacks in sensitive individuals (WebMD)

Role of estrogen and levodopa in 1-methyl-4-pheny-l-1, 2, 3, 6-tetrahydropyridine (mptp)-induced cognitive deficit in Parkinsonian ovariectomized mice model: a comparative study

Its activity is an indicator of mitochondrial biogenesis

However, for patients who want nutritional metabolic support especially those with identified deficiencies in choline or B vitamins they may provide a reasonable complement to evidence-based weight management strategies