Figure 1 2.1 Glutamine uptake and transport in cancer cells Glutamine uptake by cancer cells is mediated by transporters ( + )-dependent transmembrane transporter encoded by the solute carrier family 1 member 5 ( SLC1A5 ) gene, mediates the cellular uptake of glutamine and other neutral amino acids and is considered to be a primary glutamine transporter in cancer cells ( SLC7A5 gene, preferentially transports large branched and aromatic neutral amino acids, and its expression is upregulated in various types of cancer cells ( via LAT1 with high affinity ( SLC7A11 )
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A recent study reveals that CD36 + CAFs internalize Ox-LDL to trigger lipid peroxidation, subsequently secreting macrophage migration inhibitory factor (MIF) to recruit MDSCs, thereby establishing an immunosuppressive TME (Zhu 2023).In recurrent glioblastoma, NOX4-mediated endothelial ferroptosis is upregulated, yet its underlying mechanisms require further investigation (Liang et al
10.1016/j.immuni.2013.03.009 Immunity 112 QuanC.ChenX