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Alphalipoic acid supplementation improves pathological alterations in cellular models of Friedreich ataxia

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To determine whether glutathione imbalances were capable of sensitizing hepatocytes to TNF-induced cell death, hepatocytes were pretreated with H 2 O 2 (0.1 and 0.2 mM) for 2 h, followed by TNF addition (40 ng/mL)

however, the precise role attributed to acetate in this regard still remains to be clarified