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Evidence from clinical studies suggests that VE, either alone or in combination with other compounds, can significantly reduce pro-inflammatory cytokines such as IL-6, TGF-1, and MCP-1, while enhancing anti-inflammatory mediators including IL-10 and adiponectin

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doi: 10.1152/ajpcell.00139.2004 14 Calderon-CortesE.Cortes-RojoC.Clemente-GuerreroM.Manzo-AvalosS.Villalobos-MolinaR.BoldoghI.et al

Many users report initial improvements in pain and inflammation within 1 to 2 weeks