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Mitochondrial Dysfunction Plays a Central and Multifaceted Role in Parkinson's Disease Mitochondrial dysfunction plays a fundamental and complex role in many neurodegenerative disorders, including PD (Grimm and Eckert, Figure 1), variations to mitochondrial dynamics, calcium (Ca 2+ ) imbalance and possibly other indirect influences on mitochondrial function from unrelated pathways (Park et al., 2018

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Biogenesis of ironsulfur proteins in eukaryotes: components, mechanism and pathology