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In stark contrast, exogenous lactate administration at moderate doses in experimental settings reveals a protective, pharmacodynamic potential

Effect of treatment on the number and size of bound GTP vesicles and rapid Nrf2 activation in 3xTg-AD hippocampal neurons We hypothesized that impaired vesicular endocytosis was caused by an energy shortage that resulted in a buildup of vesicles and possibly enlargement from failure to complete processing

As a result, we are unclear about the strength of direct association between VEST and clinical outcome improvement, or whether any outcomes are inferred from surrogate endpoints

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The availability of software applications to conveniently implement FBA and related in silico methods 20 has enabled the development of genome-scale models (GEMs) for more than 100 species across all three domains of life, thereby facilitating analysis of their intracellular metabolism 21