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Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: Correlation with disease activity

DNA damage results in activation of ATM and ATR, which results in stabilization of the TP53 protein causing increased levels of cell cycle inhibitors, including CDKN1A/p21 Cip , CDKN1B/p27 Kip1 , and CDKN1C/p57 Kip2 [33]

In another particular embodiment, the diagnostic method of the invention comprises determining in a sample from a subject the levels of at least one marker as defined in Table 6

For the determination of arteriovenous difference, we measure the partial pressure of oxygen in the samples of the flowing in and out solution of the heart using a gas analyzer BMS3Mk2 (Denmark)

In GCLC-deficient T cells, excessive ROS accumulation due to impaired GSH biosynthesis inhibits calcineurin function, thus suppressing NFAT activation and impairing T cell metabolic reprogramming