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It has been suggested that metformin displays potential beneficial effects by reducing several cardiovascular dysfunction risk factors, such as body mass index (BMI) (MD: 0.53 kg/m 2 , 95% CI 0.95, 0.12), insulin-resistance (HOMA-IR) (MD:0.50, 95% CI 0.91, 0.09), triglyceride (MD: 0.11 mmol/L, 95% CI 0.20, 0.02), plasma plasminogen activator inhibitor-1 (Ruth, Day et al.) (MD: 4.99 ng/mL, 95% CI 6.78, 3.21) (Li and Li, 2023), carotid intima-media thickness (CIMT), and flow-mediated dilation (FMD) (Wang et al., 2024) in PCOS patients

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The core proposal for investigating Pinealon should focus on its potential to protect telomeres from shortening and dysfunction, primarily through its described role in modulating oxidative stress and cellular aging pathways [1]

doi:10.1007/s12035-016-9736-2 Gaby, Alan

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