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suitable solvent is selected from: ether, propyl ether, tetrahydrofuran, acetone, methyl ethyl ketone, acetonitrile, propionitrile, ethyl acetate, n-hexane, dichloromethane, chloroform, or the mixture of any two or more solvents above

doi:10.3390/antiox11010154 Sp N, Kang DY, Kim DH, et al

There was a decrease in 3-methylhistidine (ratio: 0.6)

Concentration-dependent neurologic side effects: Cerebellar dysfunction: Nystagmus, ataxia, vertigo, dysarthria

With that being said, if you are planning on or trying to become pregnant, it is important that you check with your physician before starting a new supplement regimen