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The challenges in targeting KRAS stem from its biological characteristics, such as a smooth surface lacking deep binding pockets and its high-affinity GTP-binding activity, which made the development of small-molecule inhibitors particularly difficult

Moreover, DHA-enriched diets alleviate NAFLD-associated characteristics and ferroptosis-induced hepatic injury in zebrafish

However, HDAC6 inhibitors are poorly soluble in water which restricts their bioavailability and BBB permeability