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All authors have reviewed and revised the manuscript, approved the final manuscript as submitted, and agreed to be accountable for all aspects of the work

Furthermore, it has been shown that 2472 hour zero-calorie fasting causes liver mitochondrial oxidative stress in rats by increasing mitochondrial free radical leak and reactive oxygen species (ROS) generation at complex III level in vivo studies [45, 46]

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Specifically, ALA has been shown to inhibit activation of the nuclear factor kappa B (NF-B) signaling pathway, a key regulator of inflammatory responses