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Bacteria were incubated at 37 C, 140 rpm, microaerophilic conditions, 5% CO 2 , 10% O 2 and 85% N 2 and passaged in 72-h intervals in the presence of metronidazole, MF-01 or Metro-P3 at different concentrations (0.25, 0.5, 1, 2 MIC)

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Histologic remission 2 * Several definitions of histologic remission in ulcerative colitis have been described

The human body is capable of producing L-Carnitine, but not in sufficient quantities to meet the bodys needs

Limitations and challenges in clinical translation Although this study has confirmed that AAP NPs can effectively inhibit COC by targeting and inducing ferroptosis, their limitations and the severe challenges in clinical translation must be fully recognized and elaborated