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635 A double-blind, randomized, placebo-controlled trial of LX-9211 for pain relief and safety in DPN initially found that LX-9211 improved PDPN

Conclusion: ANA and SMA have moderate and low sensitivity for high-grade ICI hepatitis, though the prognostic implications of ANA- or SMA-positivity suggest that testing for these autoantibodies may be useful

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The compound has since remained an active subject of preclinical research, particularly in the areas of lipid metabolism, adipose tissue signaling, and exploratory tissue repair models

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