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Clinical trials have utilized doses ranging from 1 mg per day up to 30 mg per day in divided doses for various administration routes, demonstrating safety across a wide dose spectrum

Methods Mol Biol 41:229238

243 PKC also affects guanosines regulatory effects on glial cells, reducing their viability and increasing oxidative damage

Most of the B12 supplements manufactured are given to farmed animals The "natural" way of consuming B12 - from unwashed vegetables and unfiltered water in a "natural" environment - isn't a safe way for modern day humans because there are also other less desirable bacterias present in these places such as E

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