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Funding This work was supported by grants from the National Natural Science Foundation of China (82273670, 91943301, and 81973075)

The expected benefits and possible risks should be carefully evaluated before use

Loss of BMAL1 enhances nuclear factor kappa-light-chain-enhancer of activated b cells (NF-B) activation and prolongs inflammatory gene transcription in both macrophages and renal epithelial cells ( In the kidney, circadian misalignmentinduced by altered light-dark cycles or genetic manipulationleads to increased macrophage infiltration, tubular injury, and glomerular inflammation

This injection can be administered through i.v injection, however should be done so under supervision of a veterinarian

Therefore, constructing a dynamic regulatory network to fully capture such multi-target mechanisms requires integrating multidimensional data, including genomic and proteomic profiles