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The co-localization of Halo-Rac1 with EEA1 or Lamp1 progressively increased over time after EV addition in WT cells, but this increase was attenuated in CIP4 KO cells (Fig

OPA1 mutations induce mitochondrial DNA instability and optic atrophy plus phenotypes

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By blocking FcRn-mediated IgG rescue from lysosomal degradation, these agents lower circulating pathogenic IgG autoantibody titers without broadly suppressing immune cells [26]