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Erythrocyte pathology clearly indicates microcirculatory problems [208, 230, 232, 375], supporting the hypothesis that inadequate microcirculation in Long COVID, leading to ischemia-reperfusion injury, could play a critical role [352]

Macrophage migration inhibitory factor (MIF), a pleiotropic cytokine/chemokine that signals through interactions with the CD74 receptor and its auxiliary receptors CXCR2, CXCR4, and CXCR7 [168, 169], is elevated in ALD patients [170] and in mice chronically exposed to ethanol [171]

When autophagy is impaired, increased p62 competes with the DLG motif for binding to the Keap1 DC pocket and inhibits the ubiquitination of Nrf2, causing Nrf2 stabilization and the increased expression of cytoprotective genes