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Overexpression of TREK-1 suppresses BDNF-mediated plasticity, and its immunoreactivity is significantly higher in TLE-D patients than in those with TLE alone, suggesting a role in inflammation-mediated neuronal damage (Li et al., 2021)

the HGF mimics of the invention are used to treat Parkinson's disease (PD), e.g

Throughout oocyte growth, maturation, and fertilization, mitochondria supply ATP, nucleotide and amino acid precursors, and TCA cycle intermediates [2]

Since adMSCs are derived from the patient's own tissue and can be harvested in significant quantities through minimally invasive procedures, they are promising candidates for future clinical trials aimed at restoring TM function in glaucoma patients (268)

However, this method of FXN rescue would not be beneficial for non-mitotic cells such as CNS neurons