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Although a 4-carbon ketone yields approximately 22 ATP, less than the 3032 ATP produced by a 6-carbon glucose molecule, ketone oxidation is oxygen-efficient and, on a per-carbon basis, provides ATP output comparable to glucose [40, 41]

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In physiological conditions, an equilibrium exists between pro-oxidants and the enzymatic and non-enzymatic antioxidants

Another approach is to mitigate oxidative stress by administration of antioxidants such as ascorbate and Nacetyl cysteine

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