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Neuro Oncol (2023) 25(11):192031

84 Indeed, these findings are corroborated by a study demonstrating that during hypoxia, the end product of purine degradation, serum uric acid, is markedly increased, 85 a characteristic feature in patients with ARDS

PMID 28137297

169 Together, these findings question the relevance of such tumor models for humans and complicate the translation of interventions tested in mice to human subjects