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Phloridzin reduces synovial hyperplasia and inflammation in rheumatoid arthritis rat by modulating mTOR pathway

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In rats receiving MeHg + 0.4 mg/kg/day and selenium 24 g/kg/day (6.3:1 Hg:Se molar ratio) there was significant protection from toxicity, however in groups receiving MeHg + 1.2 mg/kg/day and selenium 24 g/kg/day (18:1 Hg:Se molar ratio) increasing evidence of neurological and motor injury occurred [Citation124]

However, the specific applications and exact effects of these inhibitors in AIDs need to be further explored in depth

Interestingly, adding exogenous ROS induced by TBHP led to PDCs with high expression of VRK2 susceptibility to APR-017 treatment (Fig