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In vitro studies demonstrated that at certain drug-to-target ratios, AMG 966 forms large immune complexes with TNF and TL1A, partially restoring the ability of the aglycosylated Fc domain to bind FcRIa and FcRIIa, leading to the formation of ADA

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Plitman E, de la Fuente-Sandoval C, Reyes-Madrigal F, Chavez S, Gmez-Cruz G, Len-Ortiz P, et al

Previous studies had demonstrated that the pigmented proteins from cataractous lenses possess photosensitizing capability and could generate the reactive oxygen species singlet oxygen and superoxide anion when exposed to near ultraviolet (UV) radiation at wavelengths capable of penetrating into the lens