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In clinical practice, dull or uneven skin tone is often related not only to sun exposure, but also to internal factors such as: Oxidative stress Chronic stress and lack of sleep Low-grade inflammation Reduced cellular repair capacity When these factors accumulate, skin recovery slows downeven with good skincare routines

PRDX1 stabilizes NFE2L2 by inhibiting cullin 3 (CUL3)-mediated ubiquitination, thereby promoting transcription of genes involved in GSH synthesis ( GCLC , GCLM ) and cystine import ( SLC7A11 ) 113

IV therapy ensures your body gets the nutrition it needs while the gut heals

doi: 10.1186/s10194-015-0516-6 83

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