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Given the downstream consequences of senescent cells, even when efficiently cleared by microglia, eliminating them with therapeutic interventions may potentially mitigate their abundance, reduce inflammation, and alter disease progression

Giustizieri M, Cucchiaroni ML, Guatteo E, Bernardi G, Mercuri NB, Berretta N

Activation of Beta-2 receptors results in a G s -protein mediated stimulation of adenylyl cyclase (AC) and opening of Ca-activated K channels (K Ca )