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10.1126/sciadv.aay6994 95

DOI: 10.1172/JCI8538 Kao, H.Y., Downes, M., Ordentlich, P., Evans, R.M

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Notably, disheveled (Dsh or Dvl) proteins often promote the dephosphorylation of -catenin, thereby interfering with its degradation mainly because activated Dsh proteins drive the separation of GSK-3 from the degradation complex, thereby promoting Wnt/-catenin signaling and targeting the elevation of downstream gene expression