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Lifestyle modifications include changes in diet, an increase in physical activity, and smoking cessation

31 Healthy endothelial cells regulate vascular tone in response to a complex network of signals by modulating their production of eNOS

Evidence also indicated a direct association between phases of migraine attacks and calcitonin gene-related peptide (CGRP), mitochondrial disorders, monoaminergic pathway, disruption in brain energy metabolism, and higher serum levels of glutamate and homocysteine

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