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Abstract Atherosclerosis (AS) is a common cardiovascular disease with complex pathogenesis, in which multiple pathways and their interweaving regulatory mechanism remain unclear

These findings indicate that limiting serine metabolism may have significant implications for immunotherapy, highlighting the importance of targeting these pathways in cancer therapy

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Preclinical therapies to prevent or treat fracture non-union: a systematic review

In preclinical studies, telaglenastat (CB-839), a Gln synthetase inhibitor, promoted the function of CD4 + Th 1 cells and CD8 + T cells, and inhibited the function of Th 17 cells