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This phenomenon has been documented in the brain and spinal cord dorsal horn, representing a molecular model for pain potentiation via NMDA directed intranuclear modification

Discovered in 2015 by researcher Changhan David Lee and colleagues at the University of Southern California, MOTS-c sits at the intersection of some of the most active areas in longevity science: mitochondrial biology, insulin sensitivity, skeletal muscle metabolism, and the molecular response to exercise

This original work has not been published previously nor is it under consideration elsewhere

Dihexa has been studied in preclinical models of cognitive function, Alzheimers-like neurodegeneration, and dendritic spine formation, where it has been reported to promote functional synaptogenesis with high potency in neurotrophic assays