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Clissold and Brogden, 1985

84,85 In a crossover study of healthy dogs taking the steroid prednisolone, SAMe supplementation at 10 mg/kg body weight twice daily for 42 days was found to reduce blood markers of liver oxidative damage, although the dogs still developed signs of steroid-induced liver disease

You cannot "undo" months of environmental exposure with a single dose of any nutrient

For example, a 2015 study published in BioMed Research International demonstrated that GHK-Cu increased collagen synthesis by 300% in human dermal fibroblasts, leading to thicker, more resilient skin

Skin calmness and texture often improve first, while firmness and hair fullness take longer