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The convergence of ferroptosis and syn pathology underlines the multifaceted role of dysregulated iron metabolism in exacerbating neurodegeneration in PD

Challenges in therapeutic translation Targeting specificity & off-target toxicity A major challenge is achieving cardiomyocyte-specific ferroptosis modulation without harming other cells

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Moreover, STZ triggers apoptosis and cytotoxicity by elevating reactive oxygen species (ROS) and nitric oxide synthase production

Accessed 1/12/2021, Blaussen.com staff