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In general, under physiological conditions, substances can cross the BBB through five pathways, including passive diffusion, carrier-mediated transport, adsorptive-mediated transcytosis, adsorptive-mediated transcytosis, and efflux pumps[31, 32] (Fig

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Cell Signal 122:111348 Forrest RA, Swift LP, Rephaeli A, Nudelman A, Kimura K, Phillips DR, Cutts SM (2012) Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation

The study protocol was approved by respective institutional ethics committees, i.e