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Benoist 2014, PMID 25187433) were retracted in April 2025 (retraction notices PMID 40312092 and PMID 40312093) following a Washington State University investigation that found the lead author altered images across her dissertation and multiple co-authored papers

With their diverse array of pumps and transporters, astrocytes are capable of delivering beneficial substances, including ions, neurotransmitters and metabolites, while also producing or releasing detrimental molecules, such as reactive oxygen and nitrogen species

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[7] It should not be used in individuals with hormone-sensitive tumors, such as prostate cancer or breast cancer, due to the risk of stimulating tumor growth through increased androgen or estrogen production

Preclinical studies indicate potential roles in: Supporting healthy fat metabolism and reduction of adipogenesis Improving insulin sensitivity in metabolic research models Enhancing NAD+ salvage pathway efficiency Exploring effects on energy homeostasis and longevity pathways These findings remain preliminary and confined to laboratory and animal models