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Congenital causes are rare and are the result of genetic mutations in genes encoding proteins involved in B12 absorption, transport, and intracellular processing

Amongst these compounds, 5-methyl-THF and 5,10-methyleneTHF play key roles insomuch as they orientate folate metabolism towards specific metabolic pathways (Figure 2)

Xie X, Ma G, Li X, Zhao J, Zhao Z, Zeng J